Suggestion for the clinical use of pharmacotherapies for smoking cessation

 Pharmaco theraphy  Precautions/ contraindications

 Potential Adverse effects
 Dosage  Duration  Availability

 Cost per day
 

 First line

Sustained release bupropoin

 History of seizures or eating disorder  Insomnia , dry mouth  150 mg every morning for 3 days; then 150 mg bid ( begin treatment 1-2 wks pre-quit)  7-12 wks maintainamce -up to 6 mos.  prescription only.  ~US$4  

 Nicotine gum
   mouth soreness . dyspepsia  1-24 cigarrettes / day 2 mg gum( up to 24 pieces /day)  up to 12 wks

 otc only

(USA)

 $7/10x 2mg pieces  
 Nicotine nasal spray    nasal irritation  8-40 inhalations per day  3-6 months  prascription only  $7-12 inhalations  

 Nicotine patch
   local skin reaction , insomnia

 21mg/24h --4 wks; then 14 mg/24h --2 wks; then 7mg/24h --2 wks


15 mg/16h --8wks

 prescription ?otc  $5  

 Second Line

Clonidine

 

 

 rebound hypertension

 dry mouth drowsiness dizzyness, sedation  0.15mg-0.75mg/d  3-10 wk  prescription only  $0.25 / 2 mg tablet  
 Nortryptiline  Risk of arrythmia  Sedation, dry mouth  75-100mg/ d  12 wk  prescription only  $0.75 for 75 mg  
               
               
               

Longevity

medical conditions

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